In May 1858, Mr Darling removed with his family to St Andrews, with the hope that he would find a wider scope for his enterprise in that old historic University city. The worthy-husband and his Helpmeet took with them four children who had been born to them in Dalkeith —Thirza, Margaret, Jane, and Isabella Bunyan. They opened a neat, comfortable, and unpretentious Temperance Hotel in College Street. Their sterling worth was not long in being appreciated in the new Christian circle into which they had passed; and not least by their new minister, Dr Black, now of Wellington Church, Glasgow, who, in a letter recently received, bears glowing testimony to the Christian usefulness and cheerful piety of both. But their business did not turn out so successful as they had been led to anticipate. One solid and lasting benefit they did indeed find in their new home, in the admirable education which their children received in the Madras School and College. But, meanwhile, the few busy summer months did not compensate for the long and unproductive months of winter and spring. In addition, the new Medical Act which came into force during those years, producing a great diminution in the number of candidates coming to St Andrews for the degree of Doctor of Medicine, told against them. Accordingly, after an experiment of five years, and waiting until they saw the distinct indications of Divine Providence—the motions of the "cloudy pillar"—they removed to the wider sphere of Edinburgh, where they fitted up and opened that large hotel in Waterloo Place, with which the name of "Darling" has ever since been honourably associated. Meanwhile, before leaving St Andrews, their family treasury had in one respect been made richer by the birth of their only son, Thomas Brown Darling, now practising as a successful physician in Morning-side.